In a subsequent study by the same group, engagement of B7-H4 significantly reduced cell growth of EBV-positive lymphoma cells, resulting in cell cycle arrest at G0-G1 phase via downregulation of CDK4/6, CDK2, cyclin E/D expression, phosphor-AKT, and phosphor-cyclin E and upregulation of p21 expression [21]. The gene discussed is CCNE1; the disease is lymphoma.