However, the B7-H4 positive expression rate was found to be only 17.6% in 102 cases of early-stage RCC (T1), and B7-H4 expression did not correlate with age, gender, TNM stage, lymphovascular invasion, or nuclear grade, but correlated with cancer recurrence and negatively correlated with survival [26]. The gene discussed is VTCN1; the disease is renal cell carcinoma.