In the present paper, the clinical data in support of the possible function of B7-H4 in antitumor immunity come from 26 retrospective analyses on 13 types of human cancers including the most common ones, that is, cancers of ovary, esophagus, kidney, stomach, liver, lung, colon, pancreas, breast and prostate, and melanoma. Here, VTCN1 is linked to cancer.