ALS2 and amyotrophic lateral sclerosis: According to the ALS mutation database (https://reseq.lifesciencedb.jp), there are additional ALS causative genes, including vesicle-associated membrane protein-associated protein B and C (VAMP), fusion (FUS), dynactin 1 (DCTN1), and ALS2 genes and are a total 27 ALS-related genes.