Interestingly, recent studies have demonstrated that the macrophage-recruiting chemokine, monocyte chemoattractant protein 1 (MCP-1 or CCL2), is upregulated in the glial cells of spinal cord tissues in SOD1G93A transgenic ALS mice [48], implicating the role of the brain's innate immune system and related inflammation in ALS pathophysiology. This evidence concerns the gene CCL2 and amyotrophic lateral sclerosis.