The increased PGC-1β, PGC-1α, ERRα, and PPARα transcription in 3T3-L1 and C3H/10T1/2 adipocytes was consistent with previous in vivo findings that RSG induced some [8, 9] or all [7] of these transcription factors in adipose tissues from DIO, db/db, ob/ob mice, and T2DM patients. Here, ESRRA is linked to type 2 diabetes mellitus.