These observations suggest that in a given CRC patient, there could be a few major alterations (genetic and/or epigenetic) that can be crucial for tumorogenesis e.g. key components that could disturb the WNT-pathway such as silencing of the APC gene and activation of the β-catenin gene or up-regulation of repressors of tumor suppressing genes found in patient 1. Here, APC is linked to neoplasm.