Men with locally advanced PCa (T1c–2b/N1–2/M0 or T2c–4/N0–2/M0) received 6 months of ADT with a luteinising hormone-releasing hormone (LHRH) agonist and were subsequently randomised to no additional ADT or a further 2.5 years of LHRH agonist treatment. Here, GNRH1 is linked to posterior cortical atrophy.