BRAF and differentiated thyroid carcinoma: To establish the possible association between BRAF mutations and FDG-PET positivity, Durante et al. examined the expression of several key markers of thyrocyte differentiation including NIS, Tg, thyroperoxidase, TSH receptor, transcription factor PAX8, and glucose transporter type I (GLUT1) in 56 papillary thyroid carcinoma (PTC) with BRAF mutations (i.e., BRAF-positive), 37 with no BRAF mutations (i.e., BRAF-negative), and 8 normal thyroid tissue [26].