These observations are supported by the unique mutational profile of FDG-avid tumors or metastases, namely, increased frequency of BRAF mutations leading to decreased NIS and increased GLUT1. FDG-PET positivity may be a useful potential risk factor for preoperative risk stratification in primary thyroid carcinoma and this information may help in the planning of subsequent treatment strategy such as the extent of thyroidectomy, prophylactic central neck dissection, and RAI ablation. This evidence concerns the gene BRAF and thyroid gland carcinoma.