FGF2 and neoplasm: In particular, basic fibroblast growth factor (bFGF) is characterized as a highly mitogenic factor in melanoma especially when combined with UV [26] FGF receptor 4 (FGFR4) and its Arg388 genotype [27], cell cycle regulator proteins, or genes such as p53 and others [28, 29] as well as Bcl-2 oncoprotein [28], cell adhesion defects, or cell-cell signaling mutations [29] have proven to be correlated with increased tumor thickness.