More than 10 years ago Karpe et al. [112] demonstrated a relationship between apo B48 and carotid atherosclerosis both in normotriglyceridaemic and hypertriglyceridaemic subjects An argument that the chylomicron particle could not be considered as an atherogenic particle because of its size and therefore its inability to enter the subendothelial space is no longer valid since apo B48 has been found in atherosclerotic plaques in both animal and human studies [113, 114]. Here, APOB is linked to carotid atherosclerosis.