A further recent link to the possible importance of MTP activity in the cardiac muscle in diabetes is the finding that the redox-sensitive transcription factor NF-E2-related factor 2 (NrF2) is suppressed by extracellular signaling-related kinase (ERK) leading to an increase in stress-induced insulin resistance in cardiac myocytes [62]. The gene discussed is NFE2L2; the disease is diabetes mellitus.