In this context, our previous work indicated that induction of KS-like lesions by combined FGF-2 and Tat is reproduced by combined FGF-2 and the integrin-binding Tat RGD peptide (Tat 65–80), but not by mutated Tat KGE peptide [4]. This evidence concerns the gene FGF2 and Kaposi's sarcoma.