Since either Tat or FGF-2 has been shown to modulate Bcl-2 expression by a wide variety of cell types [13–21], herein we evaluated the effects of FGF-2 and Tat, alone or combined, on Bcl-2 expression in animal and in vitro experimental models previously employed to study AIDS-KS pathogenesis. The gene discussed is TAT; the disease is AIDS.