In support of this, overexpression of TrkB-T1 but not a TrkB-T1 COOH-terminal deletion mutant in nonmetastatic pancreatic cancer cells was shown to induce liver metastasis in an orthotopic xenograft mouse model of pancreatic cancer by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation [69]. This evidence concerns the gene RHO and familial pancreatic carcinoma.