With the findings that CD4+CXCR3+ T cells in lymphocytes from MMs showed a tendency for an inverse correlation with CXCR3's ligand, CXCL10/IP10 in plasma, our results indicate a reduction of tumor immune function in asbestos-exposed patients and suggest that CXCR3, IFN-γ, and CXCL10/IP10 may be candidates to detect and monitor disease status. Here, CXCR3 is linked to neoplasm.