A more recent study comparing Der p1-specific antibody levels in children with allergic airway disease and healthy controls showed that specific IgA levels in allergic children were not significantly different from controls, but when the IgA/IgE ratio was investigated, it was found to be significantly lower in children with asthma, but not in children with allergic rhinitis as compared to controls [4]. This evidence concerns the gene IGHE and asthma.