Garro and colleagues further showed that coincubation of C. neoformans-stimulated eosinophils with CD4+ and CD8+ T cells from infected mice resulted in proliferation of T cells in an MHC 1- and 2-dependent manner, and hence eosinophils can act as antigen presenters and induce adaptive immune response to cryptococcal infection [35]. This evidence concerns the gene CD4 and cryptococcosis.