Heterogeneous expression of Tie2 in tumor vasculature suggested a role for Tie2 in tumor angiogenesis, however, elucidating the functional significance of Tie2 expression in tumors required the use of a specific Tie2 inhibitor TekdeltaFc, which is an artificial extracellular domain of Tie2 [16]. The gene discussed is TEK; the disease is neoplasm.