Interestingly, an inverse relationship between Thrombospondin-1 and VEGF production has been reported in cultured ovarian epithelial cells and LDM-CTX has been shown to decrease VEGF levels in patients with breast cancer [8], suggesting a possible relationship between VEGF expression and LDM-CTX-induced Thrombospondin-1 expression. The gene discussed is VEGFA; the disease is breast cancer.