A genomic study on 134 primary breast cancers and 27 regional or distant metastases showed a high expression of a 13-gene cluster (VEGF profile) containing VEGF, angiopoetin-like 4 (ANGPTL4), and adrenomedullin (ADM) in tumors from patients with confirmed distant disease at the time of diagnosis (i.e., MetScore = 3) [36]. This evidence concerns the gene ADM and breast cancer.