The number of microvessels that are positive for vasohibin-1 (a negative feedback regulator of angiogenesis) and vasohibin-1 mRNA levels in 17 breast ductal carcinomas in situ (DCIS) is significantly lower compared to those of 22 invasive ductal carcinomas [42]. This evidence concerns the gene VASH1 and invasive ductal breast carcinoma.