This study has, for the first time, demonstrated that maternal Mn restriction predisposes the offspring to increased central adiposity, fat deposition in liver, induction of a proinflammatory state, altered adipocyte function, dyslipidemia, and altered homeostasis of glucose and insulin possibly leading to a metabolic syndrome-like situation specially when challenged with high-fat diet in later life, a situation that prevails currently in a developing country like India. Here, INS is linked to metabolic syndrome.