One day after the first clodrolip treatment (50 μl or 200 μl), athymic male NIG(S)-Nu mice were injected with human melanoma cell line IIB-MEL-J, IIB-MEL-J-MCP-1 (IIB-MEL-J cells containing a MCP-1 expression vector) or a vehicle control. This evidence concerns the gene CCL2 and melanoma.