Similar findings are reported using the same drug regime in advanced breast cancer patients; a significant reduction in circulating VEGF level at all time-points (1, 2, 7 and 21 days after ZOL administration); moreover the most significant decrease occurred 21 days after ZOL administration with over half the patients showing a minimum of 25% reduction in circulating VEGF [81]. The gene discussed is VEGFA; the disease is breast cancer.