From our results, we can conclude that down regulation of uPA/uPAR, singly and in tandem, could be an effective therapeutic approach for inactivation of Notch-1 cleavage, signaling and trafficking and to down regulate Notch-signaling-induced NF-κB, ERK and AKT pathways which are known to play roles in growth, migration, invasion and angiogenesis of glioblastoma. This evidence concerns the gene PLAU and glioblastoma.