Germline TP53 mutations are the underlying genetic defect of Li Fraumeni Syndrome (LFS) and Li-Fraumeni-like Syndrome (LFL), a set of familial syndromes of predisposition to multiple, early cancer, characterized by an excess risk of adrenocortical carcinoma in early childhood, soft tissue sarcoma, bone sarcoma and brain tumors in adolescence, breast cancer in young adult women and multiple other cancers later in life [5]. The gene discussed is TP53; the disease is Li-Fraumeni syndrome.