For example, expression of a nNOS transgene in mdx muscles that produces an elevation of cytosolic nNOS reduces muscle fiber damage [17], reduces muscle inflammation [17], decreases skeletal muscle and cardiac fibrosis [10], [18], reduces cardiac dysfunction [18], reduces kyphoscoliosis [10], improves neurogenesis [74], provides positive allosteric regulation of phosphofructokinase [70], raises systemic levels of circulating NO [74] and reduces muscle fatigability [70]. This evidence concerns the gene NOS1 and Kyphoscoliosis.