Wolcott–Rallison syndrome (OMIM#226980) of multiple epiphyseal dysplasia and early-onset diabetes due to mutations in the EIF2AK3 gene [Delepine et al., 2000], was recently linked to microcephaly [de Wit et al., 2006], but heart disease is not reported. This evidence concerns the gene EIF2AK3 and microcephaly.