A recent analysis of data from 18 cohort studies show that delaying combination therapy until a CD4 cell count of 250/mm3 to 350/mm3 was associated with significantly higher rates of AIDS and death than starting therapy in the range of 350 to 450 CD4 cells/mm3 (HR 1.28, 95% CI 1.04-1.57) [137], and in France HIV-infected adults with a CD4 cell count greater than 500 cells/mm3 on long-term combination antiretroviral therapy reached the same mortality rates as the general population [138] after six years. The gene discussed is CD4; the disease is AIDS.