Five TFs were significantly downregulated in tumor samples (p < 0.05, Benjamini-Hochberg corrected) and had enriched binding motifs near the TSS most commonly used in the normal mucosa samples (MEIS1, NR3C1, HNF4, IKZF3 and FOXO1), whereas only two TFs, TP53 and SOX9, were found to be significantly upregulated in tumor samples (p < 0.05, Benjamini-Hochberg corrected) along with having binding enrichment near the preferred TSS of the carcinoma samples, and, interestingly, SOX9 is known to be regulated by the Wnt pathway [15]. The gene discussed is IKZF3; the disease is carcinoma.