GLRA3 and autism: This could find a support through considering the work of Shearer et al. [52] in which they observed lower Ca2+ concentrations in the hair of autistic population and that of Krey and Dolmetsch [53] in which they proved that some forms of autism are caused by failures in activity-dependent regulation of neural development due to mutations of several voltage-gated and ligand-gated ion channels that regulate neuronal excitability and Ca2+ signalling.