These information initiate our interest to measure concentrations of Na+, K+, Ca2+, Mg2+ together with caspase3 as a proapoptotic marker, IL6 and TNFα as proinflammation markers in the plasma of autistic patients from Saudi Arabia in an attempt to understand the role and relationship of these biochemical parameters in the etiology of autism and its commonly related psychiatric conditions. Here, TNF is linked to autism.