Multivariable analysis of the relation between treatment (carvedilol, metoprolol tartrate and metoprolol succinate) and serotonin induced flow also revealed no relation when diabetes, ACE inhibitor or AT antagonist treatment, treatment with statins, smoking, NYHA class, left ventricular ejection fraction (LVEF) and body mass index (BMI) were also entered in the analysis (p = 0.36). The gene discussed is ACE; the disease is diabetes mellitus.