Previous studies suggest that CLL cells can secrete antibody in response to certain stimuli such as pokeweed mitogen, or other stimuli with cytokines.[18], [19], [20], [21], [22] TLR agonists, along with cytokines IL-2 and IL-15, are well characterized in their ability to induce terminal differentiation of normal mature B cells.[23] We hypothesized that CpG along with cytokines IL-2 and IL-15 (CpG/c) could be used as a tool to induce CLL cell differentiation and alter prosurvival signaling by LEF-1 and the Wnt pathway. Here, IL2 is linked to B-cell chronic lymphocytic leukemia.