While RT-PCR and immunohistochemical analyses have shown that p42.3 is upregulated in GC compared with normal tissue samples, functional research has suggested that the depletion of p42.3 may not only result in the inhibition of GC cell proliferation and colony formation in vitro, but may also significantly reduce tumorigenicity in nude mice [3]. The gene discussed is SAPCD2; the disease is gastric cancer.