Our previous expression study reported that RORA and ROBO1 are down-regulated at least two-fold among affected individuals compared with their unaffected siblings.[28] In light of the involvement of ROBO1 and RORA in eye development, specifically the retina, and our previous expression results, we investigated the association of AMD risk with ROBO1 and the interaction of these two genes. Here, RORA is linked to age-related macular degeneration.