Therefore, our data regarding the ability of γ-flu to induce IFN-I dependent lymphocyte activation in TLR7−/− and MyD88−/− mice as well as the ability to sensitise RMA cells to lysis by influenza-immune Tc provides conclusive evidence of the ability of γ-flu to deliver internal viral proteins into the cytosol of APCs. The gene discussed is TLR7; the disease is influenza.