ERBB2 and neoplasm: For example, MCF7 tumors treated with 100 mg/kg pazopanib reached a volume of 200 mm3 at the end point with a blood vessel density of 70±14; in the MCF7 transfected with HER2 xenografts similarly treated, tumor size at the end point was larger (300 mm3), however the blood vessel density was lower (57±7).