TARDBP and amyotrophic lateral sclerosis: In the same validation analysis we also measured actinNT, whose level was already found high in PBMC of a small cohort of sALS patients and G93A SOD1 transgenic rats [11] as well as in the spinal cord of the G93A SOD1 mouse model of familial ALS [25]; and TDP-43 identified as the major component of ubiquitinated inclusions in brains of patients with ALS and frontotemporal lobar degeneration [26] and found accumulated in the cytoplasm of PBMC in a group of ALS patients [27].