For MUC1, because of the relatively continuous distribution of allele sizes, we initially used a statistical mixture fitting approach and defined a cut-point at 4.3 kb (S≤4.3 kb<L) (Figure S2A), but saw no association for allele-length genotypes and lung disease severity (p = 0.337; Figure S3A). The gene discussed is MUC1; the disease is lung disorder.