Interestingly, the other top downregulated microRNAs in the high FLAIR group, miR-127, was experimentally shown to target CXCL12 mRNA [37], a major factor for GBM invasion [25], [38], [39], [40] and also one of our top genes accounting for high FLAIR volumes (Table 4 and S1). The gene discussed is CXCL12; the disease is glioblastoma.