While revising this manuscript, it has just been reported that germ cell inactivation of Dicer1 or Drosha, an RNase III enzyme required for canonical miRNA biogenesis but not for endo-siRNA processing, both resulted in male infertility due to oligozoopsermia or azoospermia caused by constant depletion of phachytene spermatocytes and spermatids [6]. The gene discussed is DROSHA; the disease is Azoospermia.