Some cases are familial (FALS) and of these, a minority are associated with known mutation, in genes encoding SOD1 [1], Alsin [2], Dynactin 1 [3], VAPB [4], angiogenin [5], TDP43 [6], [7], or FUS [8], [9] Mutation in genes more commonly associated with other diseases can rarely present as ALS (eg. Spastin [10]) as can viral infection (eg. HIV [11] and HTLV [12]). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.