They were identified as bona fide Th17 and Th22 cells, since single IL-17A+ cells (IL-17A+IL-22-IFNγ-IL4-), single IL-22+ cells (IL-17A-IL-22+IFNγ-IL4-), in addition to double IL-17A+IL-22+ cells (IL-17A+IL-22+IFNγ-IL4-) were distinctly increased in SSc upon seven days of culture. Here, IL22 is linked to systemic sclerosis.