Of note, this positive association was observed in SSc but not in HD and was stronger with the CCR6+CCR10- CD4+ T cell subset for both IL-17A+ (r = 0.56, P = 0.013) and IL-22+ (r = 0.54, P = 0.024) CD4+ T cells (Figure 4B). Here, CD4 is linked to systemic sclerosis.