TLR4 and neuropathy: These neuropathy molecules include CGRP(↓) [21], substance P(↓) [22] and BDNF(↑) [23], neuropeptide Y(↑) [24], galanin(↑) [25] via glial activation, which in turn activates the TNFα, MCP-1 and TLR4 pathways [26,27].