However, alterations (increased staining, irregular morphology, and neurite thickness) in other regions of the brain of Smad3 null mice (pontine nuclei, cerebellar white matter, cerebral peduncle, diencephalic nuclei and internal capsule), as well as the presence of glial cells in the cerebellum and spinal cord may correlate with other synucleinopathies such as Multiple System Atrophy [47]. This evidence concerns the gene SMAD3 and multiple system atrophy.