Furthermore, HuH-28 human intrahepatic CC cell line expresses VEGF-A, VEGF-C, and related receptors, which are enhanced by stimulation with estrogens [64], and the stimulatory effect of 17beta-estradiol is blocked by estrogen receptor or insulin-like growth factor-1 receptor antagonists [64]. The gene discussed is VEGFA; the disease is cholangiocarcinoma.