Clinical examination and measurement of blood parameters like serum albumin, bilirubin, creatinine and prothrombin time can help determine the severity and progression of liver disease.The Child-Turcotte-Pugh (CTP) score and Model for End Stage Liver Disease (MELD) score are two indices that are usually used to determine the severity of liver disease in patients with cirrhosis [28] (Table 1). Here, F2 is linked to liver disorder.