EPO and chronic hepatitis C virus infection: We concluded that adding both pentoxifylline and vitamin E could ameliorate ribavirin-associated haemolysis, improving compliance and virologic clearance with combination therapy with pegylated interferon and ribavirin in patients with chronic hepatitis C. The suggested combination was cheap, safe, and effective and could replace the use of more hazards and expensive erythropoietin in our studied population, so worldwide use of this combination is recommended to verify their efficacy and safety in other genotypes of HCV patients.