As demonstrated by studies from our laboratory and others over a period of years, FeLV-induced thymic lymphomas demonstrate a distinctive pattern of oncogene activation that involves proviral integration (or retroviral transduction) of c-myc, bmi-1, pim-1 or fit-1, and frequently involves more than one of those loci in the same tumor [44,56]. Here, MYC is linked to thymus lymphoma.