BECN1 and HIV infectious disease: However, in two instances, influenza and human immunodeficiency virus (HIV) infection, some insights into mechanisms of autophagosome accumulation have been gained, and both pathogens target Beclin-1, presumably stabilizing complexes of Beclin-1, VPS34, VPS15, UVRAG and Rubicon that inhibit autophagosome maturation (Figure 2 and Table 1).