In accordance with this, treatment with specific NF-κB pathway inhibitors leads to suppression of growth and impaired tumorigenesis in mice of Tax-transformed fibroblasts [70], and induces apoptosis of HTLV-1-transformed T-cell lines and ATLL cells in vitro and in vivo [71–73]. This evidence concerns the gene CNTN2 and adult T-cell leukemia/lymphoma.