Adult, immunocompetent wild-type mice are not susceptible to wild-type filovirus infection; however, inhibition of type I IFN (via knockout of the IFN alpha/beta receptor I, STAT1, or antibody-mediated depletion of IFN alpha and IFN beta) results in lethal infection with most wild-type filoviruses [17]. Here, STAT1 is linked to infection.