Entry and infection is resistant to individual and combined siRNA-mediated down regulation of caveolin-1 and clathrin heavy chain as well as to over-expression of dominant-negative mutants of dynamin-2, caveolin-1, and eps-15 (EGF receptor pathway substrate clone No. 15, which plays a role in clathrin coated vesicle formation) [45]. The gene discussed is CAV1; the disease is infection.