IFNA1 and viral infectious disease: Since all these findings may have major clinical implications for the immunological control of viral infection, more studies are warranted in relevant study models to better characterize the innate sensors detecting HBV, the innate effectors induced by HBV, the viral determinants inducing the innate response, and the mechanisms employed by HBV to counteract cellular responses in order to establish persistent infection and resistance to exogenous IFNα administration.