MTTP and infection: On one hand, it has been reported that HCV core protein localizes to the surface of lipid droplets, that virion assembly depends on the enzymatic activity of microsomal triglyceride transfer protein (MTP) which lipidates nascent apoB lipoprotein [11] and on presence of apoB and apoE [5,16–18] (Figure 1A and B); on the other hand it has been shown that HCV-infection inhibits VLDL assembly [19].