Since chemokine binding may interfere with HIV docking, natural CCR5 ligands were evaluated as HIV competitors, with varying results: CCL3, CCL4, CCL5 and CCL8 displayed inhibiting properties to HIV, CCL7 was shown not to interfere, while CCL2 (MCP-1) even enhanced HIV infection in vitro [4]. The gene discussed is CCL5; the disease is HIV infectious disease.