CCR5 and infection: Chackerian et al. [119] used the N-terminal domain of pigtailed macaque CCR5 fused to streptavidin, which when conjugated at high densities to bovine papillomavirus major capsid protein L1 virus-like particles induces high-titer anti-CCR5 IgG that blocks infection by CCR5-tropic simian-human immunodeficiency virus (SHIV) in vitro.