Interestingly, the authors found not only a functional p53 binding site in the TLR3 promoter, but also they showed that TLR3-dependent up-regulation of IL-8 in response to dsRNA, is dependent to a great extent on p53 in the p53 wt HCT116 human colon cancer cell line [57]. The gene discussed is TP53; the disease is malignant colon neoplasm.